Weight loss powder Lorcaserin HCL for sale (CAS:846589-98-8)–PHCOKER
Raw Lorcaserin Hcl powder (846589-98-8) Description
Raw Lorcaserin hydrochloride powder is a hydrochloride obtained by reaction of lorcaserin powder with one equivalent of hydrochloric acid. Used as an anti-obesity drug. Lorcaserin hydrochloride is a 5HT2c receptor agonist indicated for use in adults with a BMI ≥30, or those with a BMI ≥27 and at least one weight-related condition like hypertension, type 2 diabetes or dyslipidemia.Lorcaserin Hydrochloride powder works by suppressing appetite and induces a feeling of satiety, and is thought to avoid the precipitation of cardiac valvular disease associated with activation of 5-HT2B receptors, the area of the brain known to play a major role in regulating hunger and food intake. By activating these receptors, Lorcaserin hydrochloride powder may decrease food consumption by decreasing appetite and making a person feel full even after eating less food than usual. was approved today by the FDA in a landmark decision after 2 years of scrutiny.
Lorcaserin hydrochloride powder is specifically indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in clinically obese adults (BMI of 30 kg/m2 or greater) and overweight adults (BMI of 27 kg/m2 or greater) with at least one weight-related comorbid condition.
Lorcaserin hydrochloride powder is used together with diet and exercise to treat obesity. It is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.
Lorcaserin hydrochloride will not treat any underlying health condition (such as heart disease, diabetes, high blood pressure). Keep taking any other medications your doctor has prescribed to treat these conditions.
Lorcaserin Hcl powder (846589-98-8) Mechanism of Action
Although the exact mechanism is unknown, it is believed to involve the selective activation of 5-HT2C receptors in the anorexigenic pro-opiomelanocortin neurons in the arcuate nucleus of the hypothalamus. This results in decreased food intake and satiety by promoting the release of alpha-melanocortin stimulating hormone, which acts on melanocortin-4 receptors.
Lorcaserin hydrochloride powder works by controlling appetite — specifically by activating brain receptors for serotonin, a neurotransmitter that triggers feelings of satiety and satisfaction. Intake of food is controlled by satiety center, located in ventromedial nucleus of hypothalamus and hunger center present in lateral hypothalamus. Various inputs from higher centers and gastrointestinal tracts converge in arcuate nucleus, where two types of neurons controlling food intake is present. Firstly, food intake stimulatory group producing agouti-related protein and neuropeptide Y; and secondly, food intake inhibitory group containing cocaine and amphetamine regulated transcript (CART) and pro-opiomelanocortin (POMC) neurons. POMC contains 5-HT 2C receptors, which when activated releases alpha-melanocyte-stimulating hormone (alfa-MSH).Both inhibitory and stimulatory neurons further projects paraventricular nucleus in the hypothalamus. Paraventricular nucleus contains melanocyte 4 receptors (MC4R) that inhibits appetite in therapeutic doses lorcaserin hydrochloride powder acts as a selective 5-HT 2C agonist on POMC neurons, which in turn causes release of alfa MSH. Further alfa MSH acts on MC4R in paraventricular nucleus in the hypothalamus, leading to decrease in appetite. In supratherapeutic doses, lorcaserin hydrochlorider also acts on 5-HT 2B and 5-HT 2A receptors.
Benefits of Lorcaserin Hcl powder (846589-98-8)
Lorcaserin HCL powder is a selective 5-HT2C receptor agonist that is thought to decrease food intake through the central POMC system. Lorcaserin HCL powder benefits:
Lorcaserin HCL powder is used together with diet and exercise to treat obesity.
Lorcaserin HCL powder is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.
Lorcaserin HCL powder will not treat any underlying health condition (such as heart disease, diabetes, high blood pressure).
Recommended Lorcaserin Hcl powder (846589-98-8) Dosage
Lorcaserin HCL powder comes in tablet form and is taken typically 1-2 times a day, with or without food. Lorcaserin must be used along with a reduced calorie diet and an exercise plan.
The recommended dose of lorcaserin hcl powder is 10 mg administered by mouth twice a day. Lorcaserin may be taken without regard to meals. Lorcaserin hcl should be discontinued in patients who fail to achieve at least a 5% weight loss by week 12 since these patients are not likely to experience meaningful weight loss with continued treatment.